Simultaneous active and passive immunization of guinea-pigs against tetanus

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Abstract
1. Simultaneous active and passive immunization of guinea-pigs using tetanus toxoid adsorbed on to aluminium hydroxide produced a higher antitoxin response than simultaneous immunization using plain toxoid. The response was also better than that produced by plain toxoid alone.2. A 24 hr. interval between the injection of plain toxoid and the subsequent injection of antitoxin gave no better results than when toxoid and antitoxin were given at the same time.3. The response to simultaneous immunization, using adsorbed toxoid, of guinea-pigs sensitized to horse serum, was superior in the first 6 weeks to that of guinea-pigs which had not been sensitized.4. The suggestion that simultaneous active and passive immunization of man should be performed with adsorbed toxoid rather than plain toxoid is supported by these results.