Effect of Aminophylline on the Secretion of Insulin, Glucagon, Luteinizing Hormone and Growth Hormone in Humans1

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Abstract
Aminophylline, which inhibits the inactivation of cyclic 3′,5′-adenosine monophosphate (cyclic AMP) by intracellular phosphodiesterase, was administered iv (25 mg/min for 20 min) to normal and adrenalectomized women and acromegalic men to evaluate indirectly the effects of increased cyclic AMP on hormonal secretion in humans. Plasma free fatty acids and insulin rose promptly and were maintained at elevated levels for 2 hr, whereas growth hormone (GH) declined and remained below basal levels throughout the same period. No alterations in plasma levels of glucose, “glucagon” or luteinizing hormone (LH) were detected. The simultaneous administration of aminophylline and propranolol, a β-adrenergic antagonist, attenuated the altered responses to aminophylline alone. Because these metabolic consequences of aminophylline, without and with propranolol, resembled those obtained by activation of β- adrenergic receptors, we suggest that, in man, inhibition of phosphodiesterase simulates β-adrenergic activity.

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