Enhancement of Cytosolic Carboxylesterase by Phenobarbital in the Rat
- 1 January 1978
- book chapter
- Published by Springer Nature
- No. 1,p. 281-283
- https://doi.org/10.1007/978-3-642-66896-8_55
Abstract
Previously suggested identity of soluble hepatic carboxylesterase and cytosolic aldehyde dehydrogenase was studied in the liver of the rr and RR rat substrains after phenobarbital administration. Results showed over 30% increase of carboxylesterase activity in all animals treated with phenobarbital. The total aldehyde dehydrogenase activity was increased only in RR substrain. These animals had no similar enhancement in the activity of carboxylesterase. The results indicate that the two enzymes are not identical.Keywords
This publication has 4 references indexed in Scilit:
- Genetic Variation of Drug-Metabolizing Enzymes in the Wistar RatActa Pharmacologica et Toxicologica, 1976
- Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamateBiochemical Pharmacology, 1976
- Autosomal genetic control of the activity of an esterase in rat hepatic microsomesBiochemical Genetics, 1974
- Genetic Aspects of Increase in Rat Liver Aldehyde Dehydrogenase Induced by PhenobarbitalScience, 1971