Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype.

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Abstract
The genetic basis for autoimmunity in NZB [New Zealand Black] mice was investigated through analysis of recombinant inbred lines produced by mating NZB mice with 2 different non-autoimmune strains. Several genes (at least 6) were necessary for the production of 8 traits characteristic of the NZB mice that were studied. No fundamental genetic defect was identified that could give rise to the various autoimmune traits studied. NZB disease apparently results from the actions of several separate genes that together result in the characteristic manifestations of autoimmunity.