Highly stereospecific arylation of (S)proline and complementary highly diastereoselective reduction of the α-amino ketone. Asymmetric synthesis of (1S,2′S)- and (1R,2′S)-phenyl(2′-pyrrolidinyl)methanol
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 412-413
- https://doi.org/10.1039/c39860000412
Abstract
Both optically active threo- and erythro-phenyl(2′-pyrrolidinyl)methanol (93–100% enantiomeric excess, 100% diastereoisomeric excess) were synthesised from (S)-proline by a stereospecific arylation and the subsequent complementary diastereoselective reduction of the α-amino ketone.Keywords
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