Biologically oriented organic sulfur chemistry. 14. Antiinflammatory properties of some aryl sulfides, sulfoxides, and sulfones

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Abstract
Sulfoxides were prepared of the general structure XArS(0)C6H4(CHR)nC02H, together with the sulfides and some of the sulfones. The products were evaluated as anti-inflammatory agents by carrageenan-edema inhibition and UV-erythema inhibition in rats. Four of the compounds had activity comparable to aspirin or phenylbutazone in 1 or the other of these assays. Sulfoxides did not seem promising as a class and usually were less active than the corresponding sulfides. The 2 most interesting compounds in these assays, o-(phenylthio)phenylacetic acid and its sulfoxide, had no significant activity in adjuvant arthritis. H bonding effects are indicated in certain of the acids by their absence in the corresponding esters.