ROLES OF INTRALUMINAL OXYGEN AND GLUCOSE IN PROTECTION OF RAT INTESTINAL-MUCOSA FROM EFFECTS OF ISCHEMIA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (2) , 60-62
Abstract
Rat ileal loops were subjected to 15 min ischemia by clamping both mesenteric and collateral vessels, after which the functional capacity of their mucosa was assessed according to their ability to accumulate phenylalanine in vitro. Groups of intestines were rinsed before being subjected to ischemia. Independent and additive protective effects were observed when the rinsing buffer was oxygenated and/or when it contained glucose. Indeed, an oxygenated, glucose-containing buffer afforded full protection to the mucosa, whereas a nitrogenated, glucose-free buffer had no action.

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