New Protein Inhibitors of Cysteine Proteinases in Human Saliva and Salivary Glands

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Abstract
New protein inhibitors of cysteine proteinases were found in human saliva and salivary glands. The inhibitory potency present in saliva against ficin is about 30% of that in serum; 1 ml of saliva gives 100% inhibition of 1 nmol of ficin. The same amount of saliva causes no inhibition of 1 nmol of trypsin. The salivary inhibitors occur as multiple forms with different isoelectirc points (pI of 4.5-4.7, 5.8, 6.8, 7.8 and 8.2) and different molecular masses of approximately 16, 11, 10, 9.5 and 9 kDa [kilodaltons]. The inhibitor forms having molecular masses of < 11 kDa have not yet been described. The salivary inhibitors have a high thermal stability and a high stability both in alkaline and acidic solutions.

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