Relation of Visual Factors to Eosinophil Rhythm in Mice

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Abstract
Eosinophil counts were obtained at 2 times of day on groups of male ad libitum-fed CBC, dba (intact and blinded) and ZRD (congenitally blind) mice, kept singly housed in a room maintained at 25. 5 [plus or minus] 0. 5[degree] C. The reversal in phase relation to the lighting cycle of eosinophil rhythm, a subsequent randomization of probably cyclic eosinophil variation in individual mice and a later trend toward resumption of synchronized cyclic eosinophil behavior were observed at definite time points after blinding. Visual stimuli appear to be the usual dominant synchronizers of the adrenal cycle in intact, fully fed, singly-housed mice. Non-photic stimuli may be dominant synchronizers in congenitally eyeless male ZRD mice.