Peripheral blood stem cell apheresis in normal donors: feasibility and yield of second collections
- 1 February 1997
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 96 (2) , 415-417
- https://doi.org/10.1046/j.1365-2141.1997.d01-2013.x
Abstract
We report 13 normal peripheral blood stem cell (PBSC) donors who had a second PBSC collection for allogeneic transplantation performed after the first. The median interval between the first and second collection was 5 months. Mobilization was achieved with filgrastim (12 μg/kg/d). No significant difference was found in the median pre‐apheresis leucocyte count (×109/l) between the two donations (40.2 v 38.5; P = 0.91). The median apheresis yield (×106 CD34+ cells/litre blood processed, first apheresis) was also similar (28 v 27.3; P = 0.91). Filgrastim‐related adverse events were comparable. These data suggest that second PBSC collections are feasible, similarly tolerated and provide comparable apheresis yields.Keywords
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