Build‐Up and Maintenance of IgG Serum Concentrations with Intravenous Immunoglobulin in Patients with Primary Humoral Immunodeficiency

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Abstract
Six patients with antibody deficiency disease and i.v. Ig substitution and their serum IgG levels were monitored for at least 6 mo. After 3 IgG infusions of 6-12 g each at intervals of 3 or 4 wk, the IgG serum concentrations were between 300-500 mg/dl in 3 patients. In the 3 other patients, higher serum levels were obtained after considerably more IgG infusions given at intervals of 8 days or less. Maintenance of subnormal levels was achieved by replacement of .apprx. 10 mg/kg body wt per day. In 1 patient, the serum IgG was kept at .apprx. 1000 mg/dl by replacement of 54 mg/kg per day, i.e., by infusions of 9 g every 3-4 days.