A monoclonal antibody against a synthetic peptide reveals common structures among spectrins and α‐actinin
- 16 November 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 224 (1) , 156-160
- https://doi.org/10.1016/0014-5793(87)80440-4
Abstract
A monoclonal antibody (Mab) against a synthetic peptide, SEDYGKDL, corresponding to one conserved sequence in the chicken α-fodrin repeats reacts in immunoblotting with avian α-spectrin and α-fodrin, both mammalian spectrins and with mammalian α-fodrin. This Mab also reacts with α-actinin in both chicken and human cells. Our results confirm the previously detected structural homology between spectrins and α-actinin and implicate their common evolutionary origin.Keywords
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