THE MODE OF ACTION OF CHLORINATED BISPHENOL ANTIBACTERIALS: Part I. Metal Chelates of Hexachlorophene and Thiobisdichlorphenol

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Abstract
2:2′-Thiobis(4:6-dichlorphenol) has been found to chelate with Fe++, Fe+++, Cu++, Mn++ and Co++ as shown by colorimetric, Potentiometrie and analytical data. Crystalline copper, iron and cobalt chelates of thiobisdichlorphenol have been isolated and their structures determined. Hexachlorophene chelates with Fe++, Fe+++ and Cu++ as demonstrated by Potentiometrie titrations in the presence and absence of metals. But stable crystalline chelates could not be isolated. The suggestion is made that the structure activity relationship in the bisphenol group of antibacterials is connected with the ability of the molecule to chelate with certain metals.

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