Lack of release of human chorionic gonadotropin by gonadotropin-releasing hormone.

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Abstract
The effects of either single injection or continuous infusion of synthetic Gn-RH [gonodotropin-releasing hormone] on plasma hCG [human chorionic gonadotropin] levels were studied in 5 pregnant women (14-38 wk gestation). No definite increase of hCG level was seen in all the cases studied. In view of large dosages of Gn-RH used in this study in comparison with its minimum effective dose for the pituitary gonadotropin release, Gn-RH seems unlikely to play a role in hCG secretion during human pregnancy.

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