Effects of peripheral and central chemoreflex activation on the isopnoeic rating of breathing in exercising humans.

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Abstract
In order to establish whether certain respiratory stimuli might be ''dyspnoeagenic'' (i.e. capable of evoking an intensity of respiratory sensation out of proportion to their influence on .ovrhdot.VE), we investigated the influence of both peripheral chemoreflex activation (induced by isocapnic hypoxia) and central chemoreflex activation (induced by hypercapnic hyperoxia) on the intensity of respiratory sensation in seven healthy adults during moderate cycle ergometer exercise. In normal subjects exercising moderately, activation of the peripheral chemoreceptors by isocapnic hypoxia evokes an intensity of respiratory sensation which is out of proportion to that evoked by an isopnoeic stimulation of the central chemoreceptors with hypercapnic hyperoxia at the same level of exercise. This supports the view that the carotid bodies appear to be dyspnoeagenic.