Toxicity Studies on Rutin

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Abstract
Rutin, a flavonol glycoside with vit. P activity, was studied for signs of acute and chronic toxicity. In rats and guinea pigs, intraven. and intraperit. injns. of 30 to 50 mg./kg., and intraven. injns. in rabbits of 100-200 mg./kg., were inocuous. The rate of growth of albino rats was not affected when the diet contained as much as 1% of rutin, and after 400 days on such a diet, histologic examination of the tissues showed no evidence of injury which could be definitely related to rutin admn. Organ wts. of the exptl. animals were normal. The length of the estrus cycle was the same in rats eating a 1% rutin diet as in control animals; reproduction was as good, and the young appeared to be as healthy. On the basis of the criteria employed, rutin is non-toxic both acutely and chronically.

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