Action of Vitamin a on Liver Homogenate Oxidation of Tricarboxylic Acid Cycle Intermediates
- 1 December 1963
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 81 (4) , 383-386
- https://doi.org/10.1093/jn/81.4.383
Abstract
Vitamin A deficiency in young male albino rats results in a markedly elevated rate of oxidation of pyruvate, citrate, α-ketoglutarate, succinate, glutamate and fumarate, but not β-hydroxybutyrate and caprylate by liver homogenates. This effect was not observed with kidney or heart preparations and it was not due to reduced food consumption. The administration of vitamin A to deficient animals reduced the oxidation rates to normal values within 48 hours.Keywords
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