Treatment of severe chronic idiopathic thrombocytopenic purpura in adults with high-dose intravenous gammaglobulin

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Abstract
Patients (12) with severe chronic idiopathic thrombocytopenic purpura (ITP) were treated with i.v. polyvalent intact Ig (0.14-0.4 g/kg body weight for 5 d [day]) because of various bleeding episodes or prior to surgery. In 9 patients a significant rise in platelet counts was noted, starting on d 2 and reaching its maximum between d 4 and 11. Platelet counts decreased slowly, approaching pre-treatment values after 20 d in most cases. Response to Ig was reproducible, when infusions were repeated. Response to high-dose Ig was independent of age of patients and duration of disease. Platelet-associated IgG decreased in all patients tested. A pepsin-treated Ig preparation was ineffective in 3 patients.