Fertility in cows after treatment with a prostaglandin analogue with or without progesterone

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Abstract
Two injections each of 500 .mu.g cloprostenol (ICI-80,966), a synthetic analogue of PGF2.alpha., [prostaglandin F2.alpha.] 11 or 12 days apart or pretreatment for 7 days with progesterone from an intravaginal silastic coil and 1 injection of 500 .mu.g cloprostenol were both effective in synchronizing estrus in heifers or nursing beef cows. After 2 inseminations at 72 and 96 h after the end of treatment, the calving rate for cows observed in estrus after both treatments or for cows that had estrous-like mucus after the progesterone+cloprostenol treatment did not differ from that of control cows, but was significantly (P < 0.025) lower for cows diagnosed as ready for insemination by the characteristics of mucus after the 2 injections of cloprostenol. Treated cows diagnosed per rectum as having inactive ovaries had a significantly (P < 0.005) lower calving rate than those diagnosed as having active ovaries at the start of treatment. Significantly (P < 0.005) more treated than control cows were inseminated and became pregnant in the 1st 15 days of the treatment period, but the overall level of reproductive efficiency was low.

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