Interaction of ambient temperature with the effects of ? 9 on brain catecholamine synthesis and plasma corticosterone levels

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Abstract
The effects of Δ 9 (THC) on body temperature, catecholamine synthesis and plasma corticosteroid levels were examined in the mouse at ambient temperatures of 31°, 20° and 10°C in order to study the role of hypothermia in THC's other actions. THC produced hypothermia at 10° and 20°C, but not at 31°C. Dose related increases in dopamine and norepinephrine synthesis rates and plasma corticosterone levels were produced by THC at bot 31° and 20°C. The effects of THC at 10°C were biphasic. These data indicate that the effects of THC on brain catecholamines are not a result of drug induced hypothermia and may be a result of a direct action on neurons.