Total Synthesis of (−)-Cassine
- 13 December 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (1) , 27-29
- https://doi.org/10.1021/ol0201916
Abstract
The PdCl2-catalyzed cyclization of amino allylic alcohol 16 gave the cyclized product 17a with excellent diastereoselectivity. The versatility of compound 17a as the building block for synthesizing cis-2,6-disubstituted piperidine alkaloids has been demonstrated by a total synthesis of (−)-cassine (1).Keywords
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