EVIDENCE FOR THE PARTICIPATION OF ENDOGENOUS OPIOIDS IN THE SYMPATHOADRENAL RESPONSE TO HYPOGLYCAEMIA IN MAN
- 1 January 1985
- journal article
- clinical trial
- Published by Wiley in Clinical Endocrinology
- Vol. 22 (1) , 49-56
- https://doi.org/10.1111/j.1365-2265.1985.tb01064.x
Abstract
The effects of the long acting met-enkephalin analogue D-Ala2-MePhe4-met-enkephalin-O-ol (DAMME) and the opiate antagonist naloxone on the plasma catecholamine responses to insulin-induced hypoglycaemia have been investigated in two separate studies. DAMME depressed basal noradrenaline and adrenaline at 15 min, and blunted both the noradrenaline and adrenaline responses to hypoglycaemia. Naloxone did not alter basal plasma catecholamines, but caused a significant enhancement of the adrenaline response to hypoglycaemia. Neither DAMME nor naloxone altered the blood glucose response to insulin-induced hypoglycaemia. These data are consistent with an inhibitory modulation of endogenous opioids in the sympathoadrenal response to insulin-induced hypoglycaemia in manKeywords
This publication has 30 references indexed in Scilit:
- Cardiovascular Effects of Endogenous Opiate SystemsAnnual Review of Pharmacology and Toxicology, 1983
- Evidence that Inhibition of Nicotine‐Mediated Catecholamine Secretion from Adrenal Chromaffin Cells by Enkephalin, β‐Endorphin, Dynorphin (1‐13), and Opiates is not Mediated via Specific Opiate ReceptorsJournal of Neurochemistry, 1982
- Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.Journal of Clinical Investigation, 1982
- PRESSOR EFFECT OF NALOXONE IN SEPTIC SHOCKThe Lancet, 1981
- Isolation of human met-enkephalin and two groups of putative precursors (2K-pro-met-enkephalin) from an adrenal medullary tumourBiochemical and Biophysical Research Communications, 1980
- Modulation of nicotinic receptors by opiate receptor agonists in cultured adrenal chromaffin cellsNature, 1980
- Regional distribution of methionine-enkephalin- and beta-endorphin-like immunoreactivity in human brain and pituitaryBrain Research, 1979
- ENDOGENOUS OPIOID PEPTIDES IN NEURONS OF THE HUMAN BRAINThe Lancet, 1978
- The Cardiovascular Effects of Morphine THE PERIPHERAL CAPACITANCE AND RESISTANCE VESSELS IN HUMAN SUBJECTSJournal of Clinical Investigation, 1974
- CLINICAL STUDIES ON MORPHINE. II. THE EFFECT OF MORPHINE UPON THE CIRCULATION OF MAN AND UPON THE CIRCULATORY AND RESPIRATORY RESPONSES TO TILTINGAnesthesiology, 1946