PHARMACOKINETICS OF INSULIN INFUSED INTRA-PERITONEALLY VIA PORTABLE PUMPS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 11  (3) , 170-173
Abstract
Plasma free insulin was measured repeatedly for 4 h following a standardized breakfast in 20 C-peptide negative chronically pumped type I diabetic patients and 5 normal subjects. In the former group, insulin was given as a 1 u/h basal infusion and a 1 h superimposed meal-dose of 6 U via a peritoneal i.p. catheter lying in the low (n = 10), or in the mid-abdomen (n = 10). The results of the i.p. patients were correlated with glycosylated Hb and home capillary blood glucose. Fasting-free insulin of i.p. patients was lower than those of normals (14.7 .+-. 0.5 vs. 21.0 .+-. 1.3 mU/l, P < 0.01). Dose-induced peak occurred similary in i.p. patients and normals (70 .+-. 6 vs. 70 .+-. 12 min). Values tended to baseline after 165 .+-. 15 and 185 .+-. 22 min. in IP patients and normals (not significant). Results of the mid, and, low peritoneum subgroups differed only for peak values (31.5 .+-. 2.9 vs. 25.0 .+-. 1.6 mU/l, respectively) and did not correlate with diabete control.