Retinoblastoma family genes
Open Access
- 28 August 2006
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 25 (38) , 5190-5200
- https://doi.org/10.1038/sj.onc.1209651
Abstract
The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions are much less well characterized. Therefore, this review will primarily focus on Rb and E2F interactions. In addition to cell cycle regulation, studies of Rb and E2F proteins in animal models have revealed important roles for these proteins in apoptosis and differentiation. Recent screens of Rb/E2F target genes have identified new targets in all these areas. In addition, the mechanisms determining how different subsets of target genes are regulated under different conditions have only begun to be addressed and offer exciting possibilities for future research.Keywords
This publication has 125 references indexed in Scilit:
- Drosophila E2F1 Has Context-Specific Pro- and Antiapoptotic Properties during DevelopmentDevelopmental Cell, 2005
- Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130Genes & Development, 2004
- Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target GenesCell, 2004
- Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryNature, 2003
- Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription FactorMolecular and Cellular Biology, 2003
- Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phaseOncogene, 2003
- dE2F2, a Novel E2F-Family Transcription Factor inDrosophila melanogasterBiochemical and Biophysical Research Communications, 1998
- Coordination of Growth and Cell Division in the Drosophila WingCell, 1998
- Differential regulation of E2F transactivation by cyclin/cdk2 complexes.Genes & Development, 1994
- Effects of an Rb mutation in the mouseNature, 1992