Management of chloroquine-resistant falciparum malaria

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Abstract
Chloroquine-resistant falciparum malaria must be considered in the differential diagnosis of every illness occurring in returnees from Southeast Asia or South America. Repeated thick and thin smears should be studied for malaria parasites in every such febrile illness. Aggressive and early therapy with quinine prevents serious illness and potentially fatal complications. Oral administration is advised at the very earliest practicable moment. Pyrimethamine added to quinine therapy and followed by dapsone therapy reduces recrudescence rates to approximately 5%. While falciparum malaria from Southeast Asia is resistant to chloroquine. This drug is still the drug of choice for vivax malaria.

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