Polyostotic fibrous dysplasia with thyrotoxicosis. Report of a complete autopsy and skeletal reconstruction

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Abstract
A report is made of a patient with polyostotic fibrous dysplasia with cutaneous pigmentation and thyrotoxicosis who died of cardiopulmonary disease. This is the 7th report of postmortem examination of a patient with Albright''s syndrome. The reconstructed skeleton is believed to be the only one of this kind in the United States. Review of this and other cases fails to reveal a single cause for the skeletal and extraskeletal manifestations of the disorder; no neurologic or endocrinologic cause can be ascertained. It is likely that the condition is due to an embryologic disturbance of unrelated genes.

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