In 1975 The Memorial and Endowment Fund for Children of the American Academy of Pediatrics very kindly made me one of its first grant recipients for a research project performed in an office practice setting. Dr. Gerald Hughes of the Academy invited several of us so favored to present the results of our sudies at the annual meeting in New York in November 1977. Since my report1 had just been published in Pediatrics, I summarized it rather briefly and then moved on to discuss the larger subject of doing clinical research in office practice. It seemed possible that those remarks, slightly expanded, might be of interest to some who were not present at that meeting. There has been very little written on this matter.