No Association between Polymorphisms in theHistone DeacetylaseGenes and the Risk of Lung Cancer

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Abstract
Histone deacetylases (HDAC) mediate changes in chromatin structure by removing acetyl groups from the core histones, and they play an important role in the regulation of gene expression (1). HDACs are involved in cell cycle progression, differentiation, and apoptosis, and their deregulation is associated with several cancers (1, 2). Several candidate polymorphisms in the HDAC genes have been deposited in public databases (http://www.ncbi.nlm.nih.gov/SNP). Although the functional effects of these polymorphisms have not been elucidated, we have hypothesized that some of these variants and particularly their haplotypes may have an effect on HDAC activities and thus modulate the susceptibility to lung cancer. To test this hypothesis, a case-control study was conducted to evaluate the association between the HDAC genotypes/haplotypes and the risk of lung cancer.

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