InterPro in 2011: new developments in the family and domain prediction database
Top Cited Papers
Open Access
- 16 November 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 40 (D1) , D306-D312
- https://doi.org/10.1093/nar/gkr948
Abstract
InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites, and makes it freely available to the public via Web-based interfaces and services. Central to the database are diagnostic models, known as signatures, against which protein sequences can be searched to determine their potential function. InterPro has utility in the large-scale analysis of whole genomes and meta-genomes, as well as in characterizing individual protein sequences. Herein we give an overview of new developments in the database and its associated software since 2009, including updates to database content, curation processes and Web and programmatic interfaces.Keywords
This publication has 28 references indexed in Scilit:
- Dasty3, a WEB framework for DASBioinformatics, 2011
- The InterPro BioMart: federated query and web service access to the InterPro ResourceDatabase: The Journal of Biological Databases and Curation, 2011
- PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology ConsortiumNucleic Acids Research, 2009
- PROSITE, a protein domain database for functional characterization and annotationNucleic Acids Research, 2009
- The IntAct molecular interaction database in 2010Nucleic Acids Research, 2009
- The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databasesNucleic Acids Research, 2009
- SMART 6: recent updates and new developmentsNucleic Acids Research, 2008
- HAMAP: a database of completely sequenced microbial proteome sets and manually curated microbial protein families in UniProtKB/Swiss-ProtNucleic Acids Research, 2008
- TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomesNucleic Acids Research, 2006
- The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB dataNucleic Acids Research, 2006