Head injury therapies
- 1 October 1997
- journal article
- Published by Informa Healthcare in Expert Opinion on Investigational Drugs
- Vol. 6 (10) , 1511-1526
- https://doi.org/10.1517/13543784.6.10.1511
Abstract
The results of clinical trials in traumatic brain injury have to date been disappointing, despite promising results with animal models. Some of the agents which have been tested in clinical trials and some which are currently under evaluation are reviewed, and possible reasons for the lack of clinical benefit are discussed.Keywords
This publication has 60 references indexed in Scilit:
- Alterations in Regional Brain Catecholamine Concentrations After Experimental Brain Injury in the RatJournal of Neurochemistry, 1994
- Mechanisms of impact head injuryInternational Journal of Impact Engineering, 1994
- Muscarinic cholinergic receptor binding in rat brain at 15 days following traumatic brain injuryBrain Research, 1994
- Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for TherapyJournal of Neurotrauma, 1994
- Ultrastructural evidence of axonal shearing as a result of lateral acceleration of the head in non-human primatesActa Neuropathologica, 1993
- An Analysis of the Time-Dependent Changes in Intracellular Calcium Concentration in Endothelial Cells in Culture Induced by Mechanical StimulationJournal of Biomechanical Engineering, 1993
- Traumatic brain injury: A silent epidemicAnnals of Neurology, 1990
- Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the catBrain Research, 1987
- Excitotoxity and the NMDA receptorTrends in Neurosciences, 1987
- Ischaemic brain damage in fatal non-missile head injuriesJournal of the Neurological Sciences, 1978