PHARMACOKINETIC AND CLINICAL PHARMACOLOGICAL STUDIES WITH MEPIVACAINE AND PRILOCAINE
Open Access
- 1 June 1979
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 51 (6) , 481-485
- https://doi.org/10.1093/bja/51.6.481
Abstract
The tolerance and pharmacokinetic properties of mepivacaine and prilocaine were compared following i.v. infusion of 250 mg (0.88 and 0.97 mmol respectively) of each drug in five healthy volunteers. Side-effectrs were minor and occurred in only two subjects during the infusion of mepivacaine. Plasma concentrations of mepivacaine were greater in each subject than the corresponding values for prilocaine. The elimination half-life of mepivacaine was generally longer than that for prilocaine, whereas the total body clearance of prilocaine was consistently greater than the corresponding value for mepivacaine. For each subject the clearance of prilocaine substantially exceeded normal heptic blood flow and therefore an extra-hepatic site of metabolism of prilocaine has been postulated.This publication has 1 reference indexed in Scilit:
- Studies on the Absorption, Distribution and Metabolism of Labelled Prilocaine and Lidocaine in some Animal SpeciesActa Pharmacologica et Toxicologica, 1966