Signalling shortcuts: cell-surface receptors in the nucleus?
- 1 September 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 3 (9) , 697-702
- https://doi.org/10.1038/nrm905
Abstract
Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.Keywords
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