PITUITARY FUNCTION IN DOWN'S SYNDROME

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Abstract
Pituitary function studies were carried out in 8 male and 8 female patients with Down''s syndrome who were suspected of having hypothyroidism secondary to pituitary deficiency. In all cases, the response of human growth hormone to hypoglycemia was adequate and the response of luteinizing hormone [LH] and follicle stimulating hormone [FSH] to the injection of LH and FSH was not significantly greater than that in age and sex-matched institutionalized controls. There is no evidence that the relative hypothyroidism in these patients is due to pituitary hypofunction, nor do the results provide evidence of pituitary deficiency in Down''s syndrome generally.

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