Cerebral Edema in Diabetic Ketoacidosis

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Abstract
Cerebral edema causes or contributes to death in diabetic ketoacidosis under two distinct circumstances — in comatose patients and during treatment in conscious patients.In 1936 Dillon et al.1 found cerebral edema in eight patients, primarily adults who presented in coma after 1 to 3 days of ketoacidosis uncomplicated by infection and who died within 2 to 24 hours, after half had substantial improvements in hyperglycemia and acidemia. The terminal phase was marked by shock and fever, which usually developed after the start of treatment. All patients had widespread cerebral capillary dilation, endothelial-cell "degeneration," and perivascular and pericellular edema, without . . .