Use of Radioiodinated Antipyrine to Measure Liver Function in the Rat.

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Abstract
To determine whether impaired liver function interferes with the release of I131 tag from radioiodinated antipyrine (RIAP), groups of rats were functionally hepatectomized, poisoned with carbon tetrachloride or poisoned with dl-ethionine. RIAP was then injected intravenously and the diffusibility of the I131 tag through a cellophane membrane measured after one hour. Functional hepatectomy resulted in a marked decrease in diffusibility, while carbon tetrachloride and dl-ethionine poisoning significantly decreased diffusibility. Return of liver function after carbon tetrachloride poisoning resulted in increased deffusibility. The data support the conclusion that the release of I131 tag from RIAP is a function of, and can be used to measure, liver function.