CONVERSION OF [4-14C]PROGESTERONE TO ANDROSTENEDIONE IN VITRO BY THECAL TISSUE FROM THE OVARY OF THE DOMESTIC FOWL (GALLUS DOMESTICUS)

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Abstract
The conversion of [4-14C]progesterone to androstenedione by thecal tissue homogenates from the large yellow follicles of the hen ovary was measured at two periods of the ovulatory cycle after incubation for 1 h in the presence of cofactors. Production of androstenedione by the largest follicle, F1, was reduced significantly 1–2 h before ovulation compared with 15 h before ovulation, whereas production of an unidentified androgen increased. These differences were not observed in the next largest follicles, F2 and F3. Thecal tissue homogenates from all the follicles converted [4-14C]progesterone to 17 α-hydroxyprogesterone, androstenedione and testosterone.