ALLERGY TO BETA-LACTAMINS - DIAGNOSIS INVIVO AND CORRELATIONS WITH TESTS INVITRO (LYMPHOCYTE-TRANSFORMATION AND SPECIFIC IGE)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 105  (6-7) , 609-614
Abstract
A comparative study of the results of skin tests and tests in vitro (lymphocyte transformation [LT] and RAST [radioallergosorbent test] for specific Ig[immunoglobulin]E) in 21 patients allergic to penicillin or penicillin-derivates revealed that tests in vivo are more sensitive and reliable than LT and RAST. Future research for more valuable tests in vitro is needed, such as specific histamine-release by leukocytes or determination of IgG4 reagins by RAST procedure. A method of diagnosis of .beta.- lactamin hypersensitivity by skin tests, including penicilloylpolylysine, benzyl-penicillin, ampicillin and cephalosporin, is suggested; this method was tested in 21 patients and 23 control subjects and was safe and reproducible.

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