NAD to the Rescue
- 13 August 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5686) , 954-955
- https://doi.org/10.1126/science.1102497
Abstract
Identified 15 years ago, the Wld mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work ( Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.Keywords
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