REFLEX HYPERPNEA AND VASOCONSTRICTION DUE TO ISCHEMIC EXCITATION OF THE CAROTID BODY

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Abstract
In anesthetized dogs carotid body chemoreceptors were vascularly segregated from carotid sinus pressoreceptors by means of complete arterial isolation of the bifurcation and the use of suitable ligatures. Carotid body ischemia caused marked chemoreceptor excitation as evidenced by reflex hyperpnea. peripheral vasoconstriction and arterial hypertension. The hyperpnea and vasoconstriction thus elicited were shown to be separate from the qualitatively similar end-actions demonstrated to result from pressoreceptive disinhibition. Excitability of the chemoreceptors by ischemia meets a requirement of the hypothesis that in general their stale of excitation is a product of the interaction of their own acid metabolism with their immediate environment.

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