Tetracycline and the colonization and infection of the mouths of germ-free and conventionalized rats with Candida albicans

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Abstract
The results of two experiments in which the mouths of germ-free and conventionalized specific pathogen-free rats, some of which had been treated with tetracycline hydrochloride, were inoculated with C. albicans are reported. The germ-free state favours carriage and infectivity with the fungus to such a degree that any complementary action of tetracycline was not demonstrated in the present experiments. Carriage and infectivity of C. albicans was less prevalent in the conventionalized rats, in whom tetracycline potentiated both carriage and infectivity. In the first experiment an incidental finding was an unusual form of gingivitis in the Candida infected germ-free rats, probably due to the infection in these animals. In germ-free rats the pattern of candidal mucosal infection after 27 weeks was different from that which occurred after 9 weeks suggesting the emergence of a host defence response between 9 and 27 weeks.

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