Acute Effects of Synthetic Surfactant Replacement on Pulmonary Blood Flow in Neonatal Respiratory Distress Syndrome

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Abstract
To assess the acute effects of surfactant replacement therapy on the pulmonary blood flow in neonatal respiratory distress syndrome (RDS), 23 distressed infants were studied before and for 1 hour after either synthetic surfactant instillation (n = 13) or endotracheal suctioning (n = 10). Doppler ultrasound was used to measure blood flow velocity and flow velocity integral, representing volumetric flow, of the left pulmonary artery branch, ductal left-to-right shunt, and ascending aorta. Surfactant instillation increased the left pulmonary artery and ductal shunt flow velocity and flow velocity integral for 1 hour in 10 of 13 treated infants, whereas no change was found after endotracheal suctioning. There was a significant (P <0.05) correlation between the changes in the pulmonary artery and ductal flow values at 1 hour after surfactant treatment. The mean increase during 1 hour after treatment in the pulmonary artery flow ranged from 15 to 25% and in the ductal left-to-right shunt from 28 to 33%. No change in the aortic flow or heart rate was found in either group. Our results thus suggest that synthetic surfactant therapy may acutely increase pulmonary blood flow and ductal left-to-right shunting in infants with RDS.

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