The distribution of salicylate in mouse tissues after intraperitoneal injection
- 1 January 1968
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 20 (1) , 58-63
- https://doi.org/10.1111/j.2042-7158.1968.tb09619.x
Abstract
The concentrations of salicylate and its principal metabolites were measured in blood, liver, brain, kidney, heart, spleen, diaphragm and skeletal muscle after the intraperitoneal injection of a fixed amount of radioactive salicylate and varying doses of unlabelled salicylate. The patterns of distribution of salicylate in the various organs with time were similar, the peak level being attained in 30–60 min after injection. Salicylate was eliminated from the blood after 8 hr but persisted in liver in measurable amounts up to 24 hr.This publication has 4 references indexed in Scilit:
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