A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase
Open Access
- 1 October 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (42) , 39456-39462
- https://doi.org/10.1074/jbc.m206452200
Abstract
No abstract availableKeywords
This publication has 50 references indexed in Scilit:
- Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine MutationsJournal of Biological Chemistry, 2000
- One-Electron Redox Potential of Thiobenzoic Acid. Kinetic Characteristics of Benzoylthiyl Radical β-FragmentationJournal of the American Chemical Society, 1998
- Ebselen in Acute Ischemic StrokeStroke, 1998
- Molecular actions of Ebselen—an antiinflammatory antioxidantGeneral Pharmacology: The Vascular System, 1995
- Ebselen, a selenoorganic compound as glutathione peroxidase mimicFree Radical Biology & Medicine, 1993
- Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activityChemico-Biological Interactions, 1992
- Characterisation and quantitation of a selenol intermediate in the reaction of ebselen with thiolsChemico-Biological Interactions, 1992
- Development of synthetic compounds with glutathione peroxidase activityJournal of the American Chemical Society, 1989
- A Novel Biologically Active Selenoorganic Compound. VIII. Biotransformation of EbselenXenobiotica, 1988
- Mechanism of the Catalytic Reduction of Hydroperoxides by Ebselen : A Selenium ‐ 77 Nmr StudyBulletin des Sociétés Chimiques Belges, 1987