Direct resolution of some phenylglycines by liquid chromatography on a chiral crown ether phase
- 1 January 1990
- Vol. 2 (3) , 200-204
- https://doi.org/10.1002/chir.530020313
Abstract
The optical resolution of a series of 12 amino acids of the phenylglycine family was studied using a chiral crown ether column. The effects of pH, temperature, and mobile phase additive were investigated. In three examples it was confirmed that the R enantiomer eluted prior to the S enantiomer. Most phenylglycines were resolved with large separation factors; those with two functional groups substituents on opposing sides of the phenyl ring, however, were not well separated.Keywords
This publication has 14 references indexed in Scilit:
- Immobilized enzymes as chromatographic phases for HPLC: The chromatography of free and derivatized amino acids on immobilized trypsinChromatographia, 1989
- Considerations of chiral recognition relevant to the liquid chromatography separation of enantiomersChemical Reviews, 1989
- Optical resolution of amino acids, peptides and hydroxycarboxylic acids using a new chiral column for ligand-exchange chromatographyJournal of Chromatography A, 1989
- The stereochemical resolution of enantiomeric free and derivatized amino acids using and hplc chiral stationary phase based on immobilized ?-chymotrypsin: Ciral separation due to solue structure or enzyme activityChirality, 1988
- The Design of Molecular Hosts, Guests, and Their Complexes (Nobel Lecture)Angewandte Chemie International Edition in English, 1988
- Direct liquid chromatographic separation of racemates with an .alpha.-cyclodextrin bonded phaseAnalytical Chemistry, 1987
- High-performance liquid chromatographic separation of amino acid enantiomers on urea derivatives of L-valine bonded to silica gelJournal of Chromatography A, 1984
- Cyclodextrin Bonded Phases For the Liquid Chromatographic Separation of Optical, Geometrical, and Structural IsomersJournal of Chromatographic Science, 1984
- Direct liquid chromatographic separation of enantiomers on immobilized protein stationary phasesJournal of Chromatography A, 1982
- Ligand-exchange chromatography of racematesJournal of Chromatography A, 1973