Evidence for oscillation of prostaglandin release from spontaneously contracting guinea pig taenia coli

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Abstract
Two strips of guinea pigs tenia coli were mounted 1-2 mm apart in a small organ bath. One of the strips was incubated before mounting with indomethacin, which inhibited release of prostaglandin [PG]E2 for at least 4 h to levels not detectable by biological assay. Both stretch-evoked contractions or spontaneous contractions of the PG-releasing strip reduced the contraction time intervals between spontaneous contractions in the paired strip. Neither stretch-evoked nor spontaneous contractions of the nonPG-releasing strip influenced spontaneous contractions in the paired strip. With the strips widely separated, stretch-evoked contractions of PG-releasing strips caused shortened contraction-time intervals in the paired strips, but spontaneous contractions had no such effect. Rat fundus, separated 1-2 mm from PG-releasing tenia coli, showed small contractions occurring at the same frequency as spontaneous tenia contractions. These rat fundus contractions were abolished by indomethacin. Data show that there is communication between the PG-releasing strip and the nonPG-releasing strip. Apparently this communication was mediated by released PGE2, and release of this mediator is augmented during spontaneous contractions of guinea pig tenia coli.

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