A Study of Ionic Equilibria in Cartilage

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Abstract
The distribution coefficients of sodium and chloride ions were determined between cartilage and sodium chloride solutions ranging in concentration from 0.005 N to 0.15 N. It was found that the ideal Donnan equilibrium held and that the mean activity coefficient of NaCl in cartilage was practically constant over the entire range of concentrations. It was hence deduced that the matrix of cartilage must have a homogeneous structure on the colloidal scale. The distribution coefficients of potassium, calcium and sulphate ions were measured between cartilage and Ringer's solution and the selectivity coefficients were calculated between these ion; and the sodium or the chloride ion. For all three ions the selectivity coefficients were found to be somewhat higher than unity, i.e., potassium and calcium are taken up by cartilage in preference to sodium and sulphate in preference to chloride.

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