EFFECTS OF CORTICOSTEROIDS ON URINARY FORMALDEHYDOGENIC CORTICOIDS AND 17- KETOSTEROIDS IN NORMAL AND SUBTOTALLY HEPATECTOMIZED RATS1

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Abstract
T TRINARY outputs of 17-ketosteroids (17-KS) and reducing (-R) or formaldehydogenic (F) corticoids (C) are used as measures of adrenal cortical function. However, they are not readily interpretable. Under different conditions, urinary 17-KS and FC can vary in the same sense or independently (Venning, 1950). Among factors contributing to this variability of relationship, the nature of the steroids undergoing metabolism is perhaps the most important. Thus, in human beings (Venning, 1950; Polley and Mason, 1950) and in rats (del Greco, Masson and Corcoran, 1952), only C-17-hydroxylated corticosteroids act as 17-KS precursors; the extent to which injected corticosteroids appear in urine as FC varies widely (Fajans, Louis and Conn, 1951 a). Among other variables are the state of esterification, the route of administration and the level of hepatic function (Fajans, Louis and Conn 1951 b; Engstrom et al., 1951; Bongiovanni and Eisenmenger, 1951).