Preparation of High Titered Rabbit Anti-Mouse IgE Sera

Abstract
A method for the consistent production of rabbit anti-mouse IgE sera is described. Rabbits were immunized intravenously with IgE-anti-normal mouse serum mixtures over 8 to 12 weeks. Ten microliters of the anti-mouse IgE sera completely neutralized all the mouse IgE in the serum (50 μl) possessing a passive cutaneous anaphylaxis titer of 20,000.