The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
- 1 December 2003
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 5 (12) , 1029-1033
- https://doi.org/10.1038/ncb1203-1029
Abstract
The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.Keywords
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