Experimental neurogenic pulmonary edema

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Abstract
Neurogenic pulmonary edema (NPE) was produced consistently in normal cats by increasing intracranial pressure with an intraventricular infusion of mock CSF. The usual elevation of systemic arterial pressure (SAP) that follows severe intracranial hypertension (the Cushing response) was controlled by blood withdrawal at variable rates to achieve and maintain constant cerebral perfusion pressure (CPP) in 3 groups of cats of 50, 20 and 0 mm Hg, respectively, for 30 min. In this model, NPE occurs in the absence of increased SAP and in the presence of decreasing CPP. Systemic arterial hypertension is apparently not an essential stimulus for the development of NPE. The lungs are apparently directly affected by the intense sympathetic discharge evoked by severe intracranial hypertension.